edta ne demek?
EDTA (Ethylenediaminetetraacetic acid)
EDTA Nedir?
EDTA bileşiği Etilendiamin tetraasetik asit'in
kısaltmasidir. EDTA polyamino karboksilik asid
bileşiğidir.
Genel formülü ise
[CH<sub>2</sub>N(CH<sub>2</sub>COOH)<sub>2</sub>]<sub>2</sub>
şeklindedir.
Yapısal formülü için;
http://upload.wikimedia.org/wikipedia/commons/thumb/8/85/Ethylenediaminetetraacetic.png/200px-Ethylenediaminetetraacetic.png
EDTA'nın Kimyasal Özellikleri
CAS No: 60-00-4
Molekül Formülü: C<sub>10</sub>H<sub>16</sub>N<sub>2</sub>O<sub>8</sub>
Molekül Ağırlığı: 292.24 g.mol<sup>−1</sup>
Yoğunluğu: 0,86 g/cm<sup>3</sup>
Erime noktası: 240 °C
Asidite;
pK1=0.0 (CO2H) (µ=1.0)
pK2=1.5 (CO2H) (µ=0.1)
pK3=2.00 (CO2H) (µ=0.1)
pK4=2.69 (CO2H) (µ=0.1)
pK5=6.13 (NH+) (µ=0.1)
pK6=10.37 (NH+) (µ=0.1)
EDTA'nın Keşfi
EDTA ilk olarak Ferdinand Munz tarafından
tanımlanmıştır. Munz, EDTA'nın keşfini
etilendiamin ve klorasetik
asit çözeltilerinden elde etmiştir.
H<sub>2</sub>NCH<sub>2</sub>CH<sub>2</sub>NH<sub>2</sub> + 4
CH<sub>2</sub>O + 4 NaCN + 4 H<sub>2</sub>O →
(NaO<sub>2</sub>CCH<sub>2</sub>)<sub>2</sub>NCH<sub>2</sub>CH<sub>2</sub>N(CH<sub>2</sub>CO<sub>2</sub>Na)<sub>2</sub> +
4 NH<sub>3</sub>
(NaO<sub>2</sub>CCH<sub>2</sub>)<sub>2</sub>NCH<sub>2</sub>CH<sub>2</sub>N(CH<sub>2</sub>CO<sub>2</sub>Na)<sub>2</sub> +
4 HCl →
(HO<sub>2</sub>CCH<sub>2</sub>)<sub>2</sub>NCH<sub>2</sub>CH<sub>2</sub>N(CH<sub>2</sub>CO<sub>2</sub>H)<sub>2</sub> +
4 NaCl
Poliamino karboksilik asid grubundan olan
EDTA’nın kimyasal yapısına bakıldığında 2 amino 4
karboksil ligandı vardır. EDTA metal iyonlarına
karşı yüksek afinite gösterir.
[Fe(H<sub>2</sub>O)<sub>6</sub>]<sup>3+</sup> + H<sub>4</sub>EDTA ⇌
[Fe(EDTA)]<sup>−</sup>+ 6 H<sub>2</sub>O + 4 H<sup>+</sup>
(K<sub>eq</sub> = 10<sup>25.1</sup>)
EDTA’nın Laboratuvarda Kullanımı
EDTA laboratuvarda metal iyonlarını tutmak için
kullanılır. Biyokimya ve moleküler
biyoloji iyon tüketici olarak enzimlere
karşı kullanılır. Analitik kimya da
kompleksometrik titrasyon, Su sertliği
maskeleyici ajanlar analizelerinde kullanılır.
Kaynakça
<small> 1 ^ Harris, D.C. "Quantitative Chemical Analysis", 7th ed., W.
H. Freeman and Compagny, New York, 2007 2 ^ F. Munz "Polyamino
carboxylic acids to I. G. Farbenindustrie, DE 718 981, 1935; US 2 130
505, 1938. 3 ^ Synthesis of EDTA 4 ^ a b c J. Roger Hart
"Ethylenediaminetetraacetic Acid and Related Chelating Agents" in
Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim,
- 5 ^ Kirchner, S. Barium (Ethylenediaminetetracetato) Cobalt(III)
4-Hydrate" Inorganic Syntheses, 1957, Volume 5, pages 186-188. 6 ^
Edta - Motm 7 ^ Holleman, A. F.; Wiberg, E. (2001). Inorganic Chemistry.
San Diego: Academic Press. ISBN 0-12-352651-5. 8 ^ Furia T (1964). "EDTA
in Foods — A technical review". Food Technology 18 (12): 1874–1882. 9 ^
a b c Lanigan RS and Yamarik TA (2002). "Final report on the safety
assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium
EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA,
trisodium EDTA, HEDTA, and trisodium HEDTA". Int J Toxicol. 21 Suppl 2:
95–142.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12396676&dopt=AbstractPlus
. Retrieved 2008-01-28. 10 ^ US Food and Drug Administration: Center for
Food Safety and Applied Nutrition Questions and Answers on the
Occurrence of Benzene in Soft Drinks and Other Beverages 11 ^ Ruth
DeBusk et al. (2002). "Ethylenediaminetetraacetic acid (EDTA)".
http://www.umm.edu/altmed/articles/ethylenediaminetetraacetic-acid-000302.htm
. Retrieved 2007-07-25. 12 ^ "Home > Medical Reference > Complementary
Medicine > EDTA overview". University of Maryland Medical Center.
http://www.umm.edu/altmed/articles/ethylenediaminetetraacetic-acid-000302.htm
. Retrieved 16 December 2009. 13 ^ Loren, Karl (1996). "I/V Chelation
Using EDTA Life Flow One The Solution For Heart Disease". The Thinking
Person's Guide to Perfect Health. Vibrant Life.
http://www.oralchelation.net/data/EDTA/data14e.htm . Retrieved 16
December 2009. 14 ^ See "les conservateurs en opthalmologie" Doctors
Patrice Vo Tan & Yves lachkar, Librarie Médicale Théa. 15 ^ Green, Saul;
Wallace Sampson (December 14, 2002). "EDTA Chelation Therapy for
Atherosclerosis And Degenerative Diseases: Implausibility and
Paradoxical Oxidant Effects". Quackwatch.
http://www.quackwatch.org/01QuackeryRelatedTopics/chelationimp.html .
Retrieved 16 December 2009. 16 ^
http://www.clinicaltrials.gov/ct/show/NCT00044213?order=2 17 ^
Margolock, David (July 26, 1995). "F.B.I. Disputes Simpson Defense on
Tainted Blood". The New York Times: pp. A12.
http://query.nytimes.com/gst/fullpage.html?sec=health&res=990CE4DD1F3DF935A15754C0A963958260
. Retrieved 16 December 2009. 18 ^ Zhiwen Yuan, Jeanne M. VanBriesen
"The Formation of Intermediates in EDTA and NTA Biodegradation"
Environmental Engineering Science 2006, volume 23, pp. 533–544.
19 ^ a b Robin L. Sheppard, and Jack
Henion (1997). "Determining EDTA in Blood" ([dead link] – Scholar
search). Analytical Chemistry 69: 477A–480A.
http://pubs.acs.org/hotartcl/ac/97/aug/det.html. Retrieved 2007-07-25.
20 ^ S. Loyaux-Lawniczak, J. Douch, and P. Behra (1999). "Optimisation
of the analytical detection of EDTA by HPLC in natural waters".
Fresenius' J. Anal. Chem. 364 (8): 727–731. .
https://web.archive.org/web/20071012154504/http://cat.inist.fr/?aModele=afficheN&cpsidt=1898737.
Retrieved 2007-07-25. 21 ^ Carolina E. Cagnassoa, Laura B. López,
Viviana G. Rodríguez and Mirta E. Valencia (May 2006). "Development and
validation of a method for the determination of EDTA in non-alcoholic
drinks by HPLC". Journal of Food Composition and Analysis 20 (3-4): 248.
22-Ege üniversitesi Deri müh.
bölümü.(G.E) www.ege.edu.tr </small>
Orijinal kaynak: edta. Creative Commons Atıf-BenzerPaylaşım Lisansı ile paylaşılmıştır.
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